Partnering Up for Cardiac Hypertrophy

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Partnering up for cardiac hypertrophy.

The heart must adapt its mechanical activity to the prevailing hemodynamic demands. When an increased demand is brought about by sustained stimuli such as growth and development, pressure overload, or mutations in sarcomeric proteins, the heart will typically undergo an increase in size caused by myocyte hypertrophy. Underlying this hypertrophic response is the coordinated interaction of distin...

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Detection of Cardiac Hypertrophy by RVM and SVM Algorithms

The meaning of the hypertropy word is the increasing size.Heart hypertropy is symptoms of increase the thickness of the heart muscle that the left ventricular hypertrophy of them is the most common.The causes of hypertrophy heart disease are high blood pressure , aortic valve stenosis and sport activities respectively. Assessment of that by using ECG signal analysis is essential Because the ris...

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In this issue of Cell, the Calmodulin binding transcription activator 2 (CAMTA2), is shown by Song et al. (2006) to be an indispensable transcription coactivator for cardiac hypertrophy. CAMTA2 is activated by the dissociation of class II histone deacetylase 5 and promotes transcription of genes involved in cardiac hypertrophy through its interaction with Nkx2-5.

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The e f i e c t of experimental cardiac hypertrophy on the e n z y m e s of the m a l a t e a s p a r t a t e shutt le aspar ta te a m i n o t r a n s f e r a s e (AAT) and m a l a t e dehydrogenase (MDH) was studied. ( l ) Aortic constrict ion in adult rats resulted in 25% cardiac hypertrophy in 2 89 weeks. Total DNA (mg per hear t ) did not change. (2 ) The proportions of mitochondrial and cy...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 2006

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.0000221823.31424.47